Krebs, Edwin Gerhard

Krebs, Edwin Gerhard

▪ American biochemist
born June 6, 1918, Lansing, Iowa, U.S.

      American biochemist, winner with Edmond H. Fischer (Fischer, Edmond H.) of the 1992 Nobel Prize for Physiology or Medicine. They discovered reversible protein phosphorylation, a biochemical process that regulates the activities of proteins in cells and thus governs countless processes that are necessary for life.

      Krebs received a medical degree from Washington University (St. Louis, Mo.) in 1943. From 1946 to 1948 he did research there under the biochemists Carl and Gerty Cori. In 1948 he joined the faculty of biochemistry at the University of Washington, Seattle, becoming full professor in 1957. In 1968 he moved to the University of California at Davis, returning to Washington University in 1977.

      During the 1950s Krebs and Edmond Fischer (Fischer, Edmond H.) began investigating the process by which muscle cells obtain energy from glycogen (the form in which the body stores sugar). The Coris had previously demonstrated that cells use an enzyme called phosphorylase to release glucose (the source of energy in cell function) from glycogen. Krebs and Fischer showed that phosphorylase could be converted from an inactive to an active form by the addition of a phosphate group taken from the compound adenosine triphosphate (ATP). The enzymes that catalyze this process are called protein kinases. Krebs and Fischer also showed that phosphorylase is inactivated by the removal of a phosphate group; this process is catalyzed by enzymes called phosphatases. Malfunctions in protein phosphorylation have been implicated in the causation of diseases such as diabetes, cancer, and Alzheimer's disease.

* * *

Universalium. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Krebs , Edwin Gerhard — (1918–) American biochemist Born in Lansing, Iowa, Krebs was educated at the University of Illinois and Washington University, Seattle, gaining his MD in 1943. For the following two years he worked as an intern and assistant resident at Barnes… …   Scientists

  • Krebs, Edwin (Gerhard) — born June 6, 1918, Lansing, Iowa, U.S. U.S. biochemist. He received his medical degree from Washington University. With Edmond H. Fischer (b. 1920), he won a 1992 Nobel Prize for the discovery of reversible protein phosphorylation, a biochemical… …   Universalium

  • Krebs, Edwin (Gerhard) — (n. 6 jun. 1918, Lansing, Iowa, EE.UU.). Bioquímico estadounidense. Se tituló de médico en la Universidad Washington. En 1992 compartió el Premio Nobel con Edmond H. Fischer (n. 1920) por el descubrimiento de la fosforilación reversible de las… …   Enciclopedia Universal

  • Edwin Gerhard Krebs — (* 6. Juni 1918 in Lansing, Iowa; † 21. Dezember 2009 in Seattle, Washington) war ein US amerikanischer Biochemiker. Krebs studierte seit dem Jahr 1936 Medizin und Chemie an der University of Illinois und an der Washington University in St. Louis …   Deutsch Wikipedia

  • Krebs — Edwin Gerhard …   Scientists

  • Medizinnobelpreis 1992: Edmond Henri Fisher — Edwin Gerhard Krebs —   Die beiden Amerikaner erhielten den Nobelpreis für die Entdeckung der Mechanismen, die die Stoffwechselvorgänge in Organismen steuern.    Biografien   Edmond Henri Fischer, * Schanghai (China) 6. 4. 1920; 1944 Abschluss des Chemie und… …   Universal-Lexikon

  • Edwin G. Krebs — Edwin Gerhard Krebs (* 6. Juni 1918 in Lansing (am Mississippi River), Iowa, USA) ist ein US amerikanischer Biochemiker. Krebs studierte seit dem Jahr 1936 Medizin und Chemie an der University of Illinois und an der Washington University in St.… …   Deutsch Wikipedia

  • Krebs — Krebs, Hans A. Krebs, ciclo de * * * (as used in expressions) Krebs, ciclo de Krebs, Edwin (Gerhard) Krebs, Sir Hans Adolf …   Enciclopedia Universal

  • Gerhard — Gerhard, Roberto * * * (as used in expressions) Domagk, Gerhard Gesell, Gerhard A(lden) Krebs, Edwin (Gerhard) Richter, Gerhard Scharnhorst, Gerhard Johann David von Schröder, Gerhard …   Enciclopedia Universal

  • Edwin — /ed win/, n. 1. Also, Eadwine. A.D. 585? 633, king of Northumbria 617 633. 2. a male given name: from Old English words meaning rich, happy and friend. * * * (as used in expressions) Julian Edwin Adderley Aldrin Edwin Eugene Jr. Armstrong Edwin… …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”