—plaguer, n./playg/, n., v., plagued, plaguing.n.1. an epidemic disease that causes high mortality; pestilence.2. an infectious, epidemic disease caused by a bacterium, Yersinia pestis, characterized by fever, chills, and prostration, transmitted to humans from rats by means of the bites of fleas. Cf. bubonic plague, pneumonic plague, septicemic plague.3. any widespread affliction, calamity, or evil, esp. one regarded as a direct punishment by God: a plague of war and desolation.4. any cause of trouble, annoyance, or vexation: Uninvited guests are a plague.v.t.5. to trouble, annoy, or torment in any manner: The question of his future plagues him with doubt.6. to annoy, bother, or pester: Ants plagued the picnickers.7. to smite with a plague, pestilence, death, etc.; scourge: those whom the gods had plagued.8. to infect with a plague; cause an epidemic in or among: diseases that still plague the natives of Ethiopia.9. to afflict with any evil: He was plagued by allergies all his life.[1350-1400; ME plage < L plaga stripe, wound, LL: pestilence]Syn. 4. nuisance, bother, torment. 6. harass, vex, harry, hector, fret, worry, badger, irritate, disturb. See bother.
* * *Infectious fever caused by the bacterium Yersinia pestis, carried by the rat flea.It usually spreads to humans only when the flea runs out of rodent hosts. It takes three forms. Bubonic, the mildest, has characteristic swollen lymph nodes (buboes) and is spread only by the flea. It accounts for three-fourths of plague cases. Pneumonic plague has extensive lung involvement and is spread in droplets from the lungs; it is often fatal in three or four days without treatment. In septicemic plague, bacteria overwhelm the bloodstream and often cause death within 24 hours, before other symptoms have a chance to develop. In the 14th century, plague ravaged Europe and Asia and was called the Black Death. Plague does not respond to penicillin, but other antibiotics are effective. Sanitary measures against fleas and rodents, quarantine, and extreme caution in handling infectious materials help to suppress epidemics. A vaccine can prevent plague.
* * *▪ diseaseIntroductioninfectious fever caused by the bacillus Yersinia pestis, a bacterium transmitted from rodents to humans by the bite of infected fleas (flea). Plague was the cause of some of the most devastating epidemics (epidemic) in history. It was the disease behind the Black Death of the 14th century, when as much as one-third of Europe's population died. Huge pandemics also arose in Asia in the late 19th and early 20th centuries, eventually spreading around the world and causing millions of deaths. Today, thanks to strict public health measures and modern antibiotics, plague no longer strikes great numbers of people, nor is it as deadly for those whom it strikes. Nevertheless, it still persists in some parts of the world where large populations of wild or domestic rodents harbour the fleas and occasionally pass them to humans.Nature of the diseasePlague is primarily a disease of rodents, and humans enter only accidentally into the usual cycle. This cycle, rodent–flea–rodent, as a rule is enzootic—that is, present in an animal community at all times but affecting only small numbers of animals. However, under certain environmental conditions the cycle reaches epizootic proportions (affecting many animals in a region at the same time). Spread of the infection among wild or domestic rodents in the vicinity of human habitations creates conditions favourable for outbreaks of human plague, for when an epizootic outbreak kills off the rodents, fleas from the dead animals fail to find another rodent host and thus begin to infest humans. Today most human cases are sporadic, occurring in rural areas by infection from wild rodents such as ground squirrels, but in the past huge numbers of persons were infected in crowded cities by fleas from domestic rodents such as the black rat.The virulence of the plague bacillus—that is, its ability to multiply in the tissues of its host and cause death—is remarkably stable and vigorous. Once ingested by a flea, it multiplies until the insect's digestive tract is blocked. When the flea bites another rodent or a human, bacilli are regurgitated into the new host and migrate through the lymphatic system to lymph nodes. There they are able produce proteins that disrupt the normal inflammatory response and that prevent their digestion by infection-fighting macrophages. With the host's immune response thus weakened, the bacilli quickly colonize the lymph nodes, producing a painful swelling and, eventually, destroying the tissue. On occasion they enter the bloodstream either directly or from the lymph nodes, bringing on a general septicemia, or blood poisoning. On postmortem examination they are found in great abundance in the lymph nodes, spleen, bone marrow, and liver.The disease in humans has three clinical forms: bubonic, pneumonic, and septicemic. Bubonic plague is the best-known form in popular lore, and indeed it constitutes about three-fourths of plague cases. It is also the least dangerous form of plague, accounting today for virtually no deaths and in the past killing only half of its victims (at a time when contracting the other forms of plague brought almost certain death). Typically, bubonic plague starts two to six days after Yersinia infection with shivering, then vomiting, headache, giddiness, and intolerance to light; pain in the back and limbs; and sleeplessness, apathy, or delirium. The most characteristic sign, however, is the subsequent appearance of one or more tender, swollen lymph nodes, or buboes, which are usually distributed in the groin and armpits. The temperature rises rapidly to 40 °C (104 °F) or higher and frequently falls slightly on the second or third day, with marked fatigue. Bubonic plague is not directly infectious from person to person; the bacillus is carried from rodent to person or from person to person by infected fleas.In pneumonic plague the lungs are extensively invaded by bacilli. The physical signs are those of a severe pneumonia (fever, weakness, and shortness of breath). Edema (filling with fluid) of the lungs soon follows, and death will almost certainly occur in three or four days if treatment is not offered. Other manifestations are insomnia, stupor, staggering gait, speech disorder, and loss of memory. Pneumonic plague is highly infectious, as the bacillus can be passed to other people in droplets expelled by coughing or sneezing. The disease can also develop as a complication of bubonic plague.In septicemic plague the bloodstream is so invaded by Yersinia that, in untreated cases, death can ensue even before the bubonic or pneumonic forms have had time to appear. It is marked by fatigue, fever, and internal bleeding. Septicemic plague can arise as a complication of bubonic plague or directly by infection from a flea bite.Plague is diagnosed first by its symptoms and by a history of possible exposure to rodents. Because the symptoms may be similar to those seen in other fevers such as tularemia, dengue, or pneumonia, positive diagnosis must await the identification of Yersinia in a laboratory test of the patient's blood, lymph, or sputum. Antibiotic therapy must be given promptly to protect the patient's life. Treatment is primarily with streptomycin or, if unavailable, gentamicin. Modern therapy has reduced the global fatality rate of plague from its historical level of 50–90 percent to less than 15 percent. The fatality rate is even lower in cases of bubonic plague and in areas where modern health care is available.Hygienic measures and elimination of rats from human habitations have virtually ended urban epidemics of plague in the developed world. Since it is impossible to eliminate rodents from the wild, the disease will always be present, but its occurrence in humans can be controlled by limiting people's exposure to infested animals. A vaccine specific for plague has been used in the past in endemic areas for people likely to be exposed to rodents and their fleas. Owing to its limited effectiveness, it is not generally available.HistoryPlague is an ancient disease that was described during classical times as occurring in North Africa and the Middle East. It is sometimes presumed to be the disease behind several historic epidemics, such as the pestilence described as striking the Philistines in the biblical book of 1 Samuel, but it is impossible to verify the true nature of these outbreaks. The first great plague pandemic to be reliably reported occurred during the reign of the Byzantine emperor Justinian I in the 6th century AD. According to the historian Procopius and others, the outbreak began in Egypt and moved along maritime trade routes, striking Constantinople in 542. There it killed residents by the tens of thousands, the dead falling so quickly that authorities had trouble disposing of them. Judging by descriptions of the symptoms and mode of transmission of the disease, it is likely that all forms of plague were present. Over the next half-century, the pandemic spread westward to port cities of the Mediterranean and eastward into Persia. Christian writers such as John of Ephesus ascribed the plague to the wrath of God against a sinful world, but modern researchers conclude that it was spread by domestic rats, which traveled in seagoing vessels and proliferated in the crowded, unhygienic cities of the era.The next great plague pandemic was the dreaded Black Death of Europe (Europe, history of) in the 14th century. By this time a highly efficient plague reservoir, the black rat (Rattus rattus), was firmly established in Europe, and the disease is supposed to have been brought along trade routes from Central Asia. The number of deaths was enormous, reaching two-thirds or three-fourths of the population in various parts of Europe. It has been calculated that one-fourth to one-third of the total population of Europe, or 25 million persons, died from plague during the Black Death. For the next three centuries outbreaks of plague occurred frequently throughout the continent and the British Isles. The Great Plague of London of 1664–66 caused more than 70,000 deaths in a population estimated at 460,000. Plague raged in Cologne and on the Rhine from 1666 to 1670 and in the Netherlands from 1667 to 1669, but after that it seems to have subsided in western Europe. Between 1675 and 1684 a new outbreak appeared in North Africa, Turkey, Poland, Hungary, Austria, and Germany, progressing northward. Malta lost 11,000 persons in 1675, Vienna at least 76,000 in 1679, and Prague 83,000 in 1681. Many northern German cities also suffered during this time, but in 1683 plague disappeared from Germany. France saw the last of plague in 1668, until it reappeared in 1720 in the port city of Marseille, where it killed as many as 40,000 people. After these last outbreaks, plague seems to have disappeared from Europe. Various explanations have been offered: progress in sanitation, hospitalization, and cleanliness; a change in domestic housing that excluded rats from human dwellings; abandonment of old trade routes; and a natural quiescent phase in the normal rise and decline of epidemic diseases. Such possibilities would have been lost on Europeans at the time, as the very concept of an infectious organism was unknown. As late as 1768 the first edition of Encyclopædia Britannica repeated the commonly held scientific notion that plague was a “pestilential fever” arising from a “poisonous miasma,” or vapour, that had been brought “from eastern countries” and was “swallowed in with the air.”The pestilential poison disturbs all the functions of the body; for unless it be expelled to the external parts, it is certainly fatal.Expulsion of the poison was thought to be best accomplished by either natural rupture of the buboes or, if necessary, lancing and draining them. Other recommended means were bloodletting, sweating, induction of vomiting, and loosening of the bowels.During the 18th and early part of the 19th century, plague continued to prevail in Turkey, North Africa, Egypt, Syria, and Greece. Once it was a maxim that plague never appeared east of the Indus River, but during the 19th century it afflicted more than one district of India: in 1815 Gujarāt, in 1815 Sind, in 1823 the Himalayan foothills, and in 1836 Rājasthān. These outbreaks merely set the stage for the third great plague pandemic, which is thought to have gained momentum in Yunnan Province, southwestern China, in the 1850s and finally reached Guangzhou (Canton) and Hong Kong in 1894. These port cities became plague distribution centres, and between 1894 and 1922 the disease spread throughout the whole world, more widely than in any preceding pandemic, resulting in more than 10 million deaths. Among the many points infected were Bombay in 1896, Calcutta in 1898, Cape Town and San Francisco in 1900, Bangkok in 1904, Guayaquil (Ecuador) in 1908, Colombo (Sri Lanka) in 1914, and Pensacola (Florida) in 1922. Almost all the European ports were struck, but of all the areas affected, India suffered the most.The third plague pandemic was the last, for it coincided with (and in some cases motivated) a series of achievements in the scientific understanding of the disease. By the end of the 19th century the germ theory of disease had been put on a sound empirical basis by the work of the great European scientists Louis Pasteur (Pasteur, Louis), Joseph Lister (Lister, Joseph, Baron Lister, Of Lyme Regis), and Robert Koch (Koch, Robert). In 1894, during the epidemic in Hong Kong, the organism that causes plague was isolated independently by two bacteriologists, the Frenchman Alexandre Yersin (Yersin, Alexandre), working for the Pasteur Institute, and the Japanese Kitasato Shibasaburo, a former associate of Koch. Both men found bacteria in fluid samples taken from plague victims, then injected them into animals and observed that the animals died quickly of plague. Yersin named the new bacillus Pasteurella pestis, after his mentor, but in 1970 the bacterium was renamed Yersinia pestis, in honour of Yersin himself.It remained to be determined how the bacillus infected humans. It had long been noticed in many epidemic areas that unusual deaths among rats preceded outbreaks of plague among humans, and this link was particularly noted in the outbreaks in India and China. The relationship was so striking that in 1897 Japanese physician Ogata Masanori described an outbreak on Formosa as “ratpest” and showed that rat fleas carried the plague bacillus. The following year Paul-Louis Simond, a French researcher sent by the Pasteur Institute to India, announced the results of experiments demonstrating that Oriental rat fleas (Xenopsylla cheopis) carried the plague bacillus between rats. It was then demonstrated definitively that rat fleas would infest humans and transmit plague through their bites. With that, massive rat-proofing measures were instituted worldwide in maritime vessels and port facilities, and insecticides were used in areas where plague had broken out. Beginning in the 1930s, sulfa drugs and then antibiotics such as streptomycin gave doctors a very effective means of attacking the plague bacillus directly.The effectiveness of these measures is told in the declining numbers of plague deaths over the following decades. From a maximum of more than one million in 1907, deaths dropped to approximately 170,000 per year in 1919–28, 92,000 in 1929–38, 22,000 in 1939–48, and 4,600 in 1949–53. Plague is no longer an epidemic disease of port cities. It is now mainly of campestral or sylvatic (that is, open-field or woodland) origin, striking individuals and occasionally breaking out in villages and rural areas where Yersinia is kept in a constant natural reservoir by various types of rodents, including ground squirrels, voles, and field mice. Some 1,000 to 3,000 people worldwide contract plague each year, and some 200 of them die. The main regions of plague are in western North America; the Andes region and Brazil in South America; a broad band across Southwest, Central, and Southeast Asia; and eastern Africa. Most cases today occur in Africa.With the rise of global terrorism, plague has come to be seen as a potential weapon of biological warfare (biological weapon). During World War II, Japan is said to have spread Yersinia-infected fleas in selected areas of China, and during the Cold War the United States and the Soviet Union developed means for spreading Yersinia directly as an aerosol—a particularly efficient way to infect people with lethal pneumonic plague. Such an attack might cause a high casualty rate in only limited areas, but it might also create panic in the general population. In response, some governments have developed plans and stockpiled medications for dealing with emergency outbreaks of plague.
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