fibrin

fibrin
—fibrinous, adj.
/fuy"brin/, n.
1. the insoluble protein end product of blood coagulation, formed from fibrinogen by the action of thrombin in the presence of calcium ions.
2. Bot. a fibrinlike substance found in some plants; gluten.
[1790-1800; FIBR- + -IN2]

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 an insoluble protein that is produced in response to bleeding and is the major component of the blood clot (coagulation). Fibrin is a tough protein substance that is arranged in long fibrous chains; it is formed from fibrinogen, a soluble protein that is produced by the liver and found in blood plasma. When tissue damage results in bleeding, fibrinogen is converted at the wound into fibrin by the action of thrombin, a clotting enzyme. Fibrin molecules then combine to form long fibrin threads that entangle platelets, building up a spongy mass that gradually hardens and contracts to form the blood clot. This hardening process is stabilized by a substance known as fibrin-stabilizing factor, or factor XIII.

      Certain rare hereditary disorders may cause malfunction of this stage of the blood-clotting mechanism. A few individuals have a hereditary deficiency of fibrinogen or produce abnormal fibrinogen. Upon injury to these persons fibrin cannot form in sufficient quantity to enable a proper clot to form. Another rare hereditary disease involves a lack of factor XIII, resulting in a condition in which bleeding is difficult to stop.

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Universalium. 2010.

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Look at other dictionaries:

  • Fibrin — Fi brin, n. [Cf. F. fibrine. See {Fiber}.] (Physiol. Chem.) 1. A white, albuminous, fibrous substance, formed in the coagulation of the blood either by decomposition of fibrinogen, or from the union of fibrinogen and paraglobulin which exist… …   The Collaborative International Dictionary of English

  • fibrin — [fī′brin] n. [ FIBR(E) + IN1] a fibrous, insoluble blood protein: in the clotting process, thrombin converts fibrinogen to fibrin monomers which polymerize to form clots …   English World dictionary

  • Fibrīn — (Fibrine), so v.w. Faserstoff. Daher Fibrinsago, ein aus einheimischen Getreidearten, sowie aus stärkestoffhaltigen Substanzen gemischtes Nahrungsmittel; wird in Milch, Wein, Bier od. Obstbrühe gekocht, bes. von Kranken genossen …   Pierer's Universal-Lexikon

  • Fibrīn — (Blutfibrin, Blutfaserstoff), ein Eiweißkörper, der sich aus einem im Blut gelöst enthaltenen Eiweißkörper, dem Fibrinogen, durch Einwirkung des im Blut enthaltenen Fibrinferments bildet, sobald das Blut das Gefäßsystem verläßt, unter krankhaften …   Meyers Großes Konversations-Lexikon

  • Fibrin — Fibrīn, Blutfaserstoff, der im Blut der Menschen und Tiere vorkommende Eiweißkörper, gerinnt an der Luft, wird durch Quirlen von Blut als weiße zähe Masse gewonnen; in verdünnten Alkalien löslich, wird vom Magen sehr leicht verdaut und ist für… …   Kleines Konversations-Lexikon

  • Fibrin — Fibrin, Faserstoff; 1) vegetabilischer F., einer der die stickstoffhaltige Reihe der Elementarbestandtheile der Pflanzen bildenden Stoffe (die übrigen sind das Pflanzeneiweiß und der Käsestoff), zusammengesetzt aus 10 Atom Protein, 1 Atom… …   Herders Conversations-Lexikon

  • Fibrin — Fibrin, die ⇒ Blutgerinnung bewirkendes unlösliches Faserprotein, das durch die Proteinase ⇒ Thrombin aus einer in der Leber gebildeten, im Blutplasma zirkulierenden löslichen Vorstufe, dem Glykoprotein Fibrinogen, gebildet wird …   Deutsch wörterbuch der biologie

  • fìbrīn — m 〈G fibrína〉 biol. bjelančevinasto vlakno u krvi, sudjeluje u zgrušavanju krvi …   Veliki rječnik hrvatskoga jezika

  • fibrin — blood clotting substance, 1800, from L. fibra (see FIBER (Cf. fiber)) + chemical suffix IN (Cf. in) (2). So called because it is deposited as a network of fibers that cause the blood to clot …   Etymology dictionary

  • fibrin — fìbrīn m <G fibrína> DEFINICIJA biol. bjelančevinasto vlakno u krvi, sudjeluje u zgrušavanju krvi ETIMOLOGIJA v. fibra (1) + in …   Hrvatski jezični portal

  • fibrin — ► NOUN Biochemistry ▪ an insoluble protein formed as a fibrous mesh during the clotting of blood. DERIVATIVES fibrinoid adjective fibrinous adjective …   English terms dictionary

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