/kahr'dee oh muy op"euh thee/, n. Pathol.
any disease of the heart muscle, leading to decreased function: usually of unknown cause.
[1960-65; CARDIO- + MYOPATHY]

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      any cardiac disease process that results in heart failure due to a decrease in the pumping power of the heart or due to an impairment in the filling of the cardiac chambers. Persons with cardiomyopathy frequently retain excess fluid, resulting in congestion of the lungs, and have symptoms of weakness, fatigue, and shortness of breath. Sometimes they develop a potentially fatal arrhythmia, or abnormal heart rhythm.

      Most cardiomyopathies are idiopathic, or of unknown cause. Specific cases are usually categorized as dilated, hypertrophic, or restrictive, according to the observed abnormality. Dilated cardiomyopathy, the most common type of the disease, is characterized by an enlarged heart with stretching of the ventricle (lower chamber) and atrium (upper chamber). The left ventricle, which pumps oxygenated blood to the body tissues, shows weakness in contraction (systolic dysfunction) and stiffness in expansion and filling (diastolic dysfunction). These dysfunctions lead to fluid retention and eventually heart failure. Preceding heart attack is known to cause the condition, as is exposure to toxic substances such as alcohol, cobalt, and some anticancer drugs.

      In hypertrophic cardiomyopathy, an abnormality that is often hereditary, the ventricles are quite small due to abnormal growth and arrangement of the cardiac muscle fibres. Thickening, or hypertrophy, of the ventricular walls results in an extremely stiff heart, and subsequent impairment of the filling of the ventricles causes pressure to rise in the heart and lungs. The increased pressure in turn leads to shortness of breath and fluid retention. Hypertrophic cardiomyopathies are commonly associated with serious arrhythmias and sudden cardiac death.

      Restrictive cardiomyopathy also is characterized by a stiff heart and impaired ventricular filling. In this case the abnormality is caused by the presence of fibrous (scar) tissue introduced by a disease such as amyloidosis. Patients display many of the symptoms of hypertrophic cardiomyopathy.

      Treatment of cardiomyopathy is directed first toward identifying the underlying disease (e.g., hypothyroidism or hypertension). Patients are treated as any patient with heart failure; indeed, all patients with heart failure have some sort of cardiomyopathy. If general treatment measures fail, patients with cardiomyopathy can sometimes be helped with heart transplantation (heart transplant). Because some forms of cardiomyopathy are inherited, individuals from families with a history of the disease are encouraged to have physical examinations, electrocardiograms, and echocardiograms done periodically. In the future, genetic screening may make it possible to detect persons at risk for developing cardiomyopathy.

James B. Young

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Universalium. 2010.

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