bufotenine

bufotenine
/byooh'feuh ten"een, -in/, n. Pharm.
a hallucinogenic bufotoxin derivative, C12H16N2O, used experimentally for its digitalislike action on the heart.
Also, bufotenin /byooh'feuh ten"in/.
[1900-05; < L bufo toad + -ten (perh. < Gk tén(on) sinew, tendon) + -INE2]

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▪ drug
      weak hallucinogenic agent active by intravenous injection, isolated from several natural sources or prepared by chemical synthesis. Bufotenine is a constituent of toad poison, the poisonous, milky secretion of glands found in the skin on the back of the animal. It was first isolated in 1934.

      Structurally, bufotenine is an indole hallucinogen that is capable of blocking the action of serotonin, which is the indole amine transmitter of nerve impulses and can be found in normal brain tissue (and in toad poison). Bufotenine also functions as a powerful constrictor of blood vessels, causing a rise in blood pressure.

      Other sources of bufotenine are the mushroom Amanita muscaria and the tropical American tree Piptadenia peregrina, the seeds of which were used at the time of the early Spanish explorations by the Indians of Trinidad and of the Orinoco Plain to make the hallucinogenic snuff called cohoba, or yopo.

      In modern medicine, bufotenine has been used only experimentally, to simulate psychotic disease states for the purpose of psychiatric study.

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Universalium. 2010.

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  • bufotenine — [byo͞o΄fə ten′ēn΄, byo͞o΄fə ten′in] n. [< ModL Bufo, genus name (< L, toad) + ten (< ?) + INE3] a poisonous hallucinogenic alkaloid, C12H16N2O, extracted from toadstools and the skin glands of toads (genus Bufo) or made synthetically …   English World dictionary

  • bufotenine and hallucinations —    Bufotenine is also known as bufotenin, dimethyl serotonin, 5 OH dimethyltryptamine (5 OH DMT), N,N dimethyl 5 hydroxytryptamine, and mappine. The name bufotenine was suggested in 1893 by the French scientists Césaire Auguste Phisalix (1852… …   Dictionary of Hallucinations

  • bufotenine — (= 3 (2 (dimethylamino) ethyl) 1H indol 5 ol; mappine) ) An indole alkaloid with hallucinogenic effects, isolated from Piptadenia spp. (Mimosidae) ; first isolated from skin glands of toad ( Bufo sp.) …   Dictionary of molecular biology

  • bufotenine — noun An alkaloid, found in the skins of some toads, related to serotonin …   Wiktionary

  • bufotenine — A psychotomimetic agent isolated from the venom of certain toads (family Bufonidae) and also present in several plants and one of the active principles of cohoba; raises the blood pressure by a vasoconstrictor action and produces …   Medical dictionary

  • bufotenine — n. hallucinogenic alkaloid present in certain plants and animals …   English contemporary dictionary

  • bufotenine — bu·fo·ten·ine …   English syllables

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