allopurinol

allopurinol
/al'euh pyoor"euh nawl', -nol'/, n. Pharm.
a substance, C5H4N4O, used primarily in the treatment of chronic gout to decrease the synthesis of uric acid.
[1960-65; appar. ALLO- + PURINE + -OL1]

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      drug used in the treatment of gout, a disease that is characterized by severe inflammation in one or more of the joints of the extremities. Allopurinol inhibits an enzyme that is necessary to form uric acid, a substance present in abnormally large amounts in the blood of persons with gout that forms solid deposits in the joints, the kidneys, and other tissues. The drug reduces the amount of uric acid produced by the body and fosters the resorption of solid deposits in the joints, thus improving joint function.

      Allopurinol is mainly used to treat the severe, chronic forms of gout. Treatment with the drug ordinarily is expected to be continued for many years, if not indefinitely. Allopurinol is preferred over drugs such as probenecid or sulfinpyrazone because it decreases the amount of uric acid excreted in the urine and thus discourages the formation of uric acid kidney stones (kidney stone).

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Universalium. 2010.

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  • Allopurinol — Général Nom IUPAC 1,2 dihydro 4H pyrazolo[3,4 d]pyrimidin 4 one No CAS …   Wikipédia en Français

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  • allopurinol — [al′ō pyoor′ə nôl΄, al′ō pyoor′ənōl΄; al΄əpyoor′ə nôl΄, al΄əpyoor′ə nōl΄] n. a white, powdery drug that is an isomer of hypoxanthine and inhibits the production of uric acid: used to treat gout …   English World dictionary

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  • Allopurinol — Strukturformel Allgemeines Freiname Allopurinol Andere Namen …   Deutsch Wikipedia

  • Allopurinol — Al|lo|pu|ri|nol [↑ allo (1), ↑ Purin u. ↑ ol (1)]; das; s: Freiname für einen als Hemmstoff der ↑ Xanthin Oxidase u. als ↑ Urikostatikum bei Gicht eingesetzten Purin Antimetaboliten. * * * Allopurinol …   Universal-Lexikon

  • allopurinol — Inhibitor of xanthine oxidase to inhibit uric acid formation; used in the treatment of gout and to retard the rapid metabolic degradation of 6 mercaptopurine. * * * al·lo·pu·ri·nol …   Medical dictionary

  • allopurinol — noun Etymology: all + purine + 1 ol Date: 1964 a drug C5H4N4O used to promote excretion of uric acid …   New Collegiate Dictionary

  • allopurinol — (= 4 hydroxypyrazolo (3,4 d) pyrimidine) A xanthine oxidase inhibitor used in the treatment of gout …   Dictionary of molecular biology

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