McArdle's disease

McArdle's disease

also called  Glycogenosis Type V,  

      rare hereditary deficiency of the enzyme glycogen phosphorylase in muscle cells. In the absence of this enzyme, muscles cannot break down animal starch (glycogen) to meet the energy requirements of exercise. Muscle activity is thus solely dependent on the availability of glucose (blood sugar) and other nutrients in the circulating blood. Victims of McArdle's disease are chronically weak because their muscles are incapable of prolonged exertion; even moderate exercise produces muscle cramping and severe pain. Unlike most other types of glycogenosis, the disease is not fatal, and the missing enzyme does not impair the functioning of other body systems. McArdle's disease is inherited as an autosomal recessive trait.

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Universalium. 2010.

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  • McArdle's disease — McArdle s disease, McBurney s point see entries alphabetized as MC Mc·Ar·dle s disease mək ärd əlz n glycogen storage disease that is inherited as an autosomal recessive trait, is marked esp. by muscle weakness and myoglobinuria, and is caused by …   Medical dictionary

  • McArdle's disease — noun an inherited disease in which abnormal amounts of glycogen accumulate in skeletal muscle; results in weakness and cramping • Hypernyms: ↑genetic disease, ↑genetic disorder, ↑genetic abnormality, ↑genetic defect, ↑congenital disease,… …   Useful english dictionary

  • McArdle's disease — an inborn error of metabolism in which a deficiency of the enzyme myophosphorylase prevents the breakdown of glycogen to lactate in exercising muscle. This results in fatigue, pain, and cramps in exercising muscles. The only treatment is… …   The new mediacal dictionary

  • McArdle's disease — Glycogen storage disease in which the defective enzyme is muscle phosphorylase …   Dictionary of molecular biology

  • McArdle's disease — noun Glycogen storage disease type V, a metabolic disorder caused by a deficiency of myophosphorylase …   Wiktionary

  • McArdle — Irish name:MacArdghail Ethnicity Irish/Celtic Information Place of origin County Monaghan, Ireland[1] Notable members …   Wikipedia

  • McArdle-Krankheit — Klassifikation nach ICD 10 E74.0 Glykogenspeicherkrankheit (Glykogenose) McArdle Krankheit …   Deutsch Wikipedia

  • McArdle-Syndrom — Klassifikation nach ICD 10 E74.0 Glykogenspeicherkrankheit (Glykogenose) McArdle Krankheit …   Deutsch Wikipedia

  • McArdle disease — McArdle disease. См. гликогеноз V типа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • McArdle disease (syndrome) — Mc·Ar·dle disease (syndrome) (mək ahrґdəl) [Brian McArdle, English neurologist, 1911–2002] see glycogen storage disease, type V, under disease …   Medical dictionary

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