- Hartline, Haldan Keffer
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born Dec. 22, 1903, Bloomsburg, Pa., U.S.died March 17, 1983, Fallston, Md.U.S. physiologist.He received his M.D. from Johns Hopkins University. Experimenting on horseshoe crabs, he was the first to record the electrical impulses sent by a single optic-nerve fibre. He found that when one of the eye's receptor cells is stimulated, others nearby are depressed, enhancing contrast and sharpening perception of shapes. He showed how simple retinal mechanisms constitute vital steps in the integration of visual information. In 1967 he shared a Nobel Prize with George Wald and Ragnar Arthur Granit.
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▪ American physiologistborn Dec. 22, 1903, Bloomsburg, Pa., U.S.died March 17, 1983, Fallston, Md.American physiologist who was a cowinner (with George Wald and Ragnar Granit) of the 1967 Nobel Prize for Physiology or Medicine for his work in analyzing the neurophysiological mechanisms of vision.Hartline began his study of retinal electrophysiology as a National Research Council Fellow at Johns Hopkins University, Baltimore, receiving his M.D. in 1927. After attending the universities of Leipzig and Munich as an Eldridge Johnson traveling research scholar, he became professor of biophysics and chairman of the department at Johns Hopkins in 1949. He joined the staff of Rockefeller University, New York City, in 1953 as professor of neurophysiology.Hartline investigated the electrical responses of the retinas (retina) of certain arthropods, vertebrates, and mollusks because their visual systems are much simpler than those of humans and are thus easier to study. He concentrated his studies on the eye of the horseshoe crab (Limulus polyphemus). Using minute electrodes in his experiments, he obtained the first record of the electrical impulses sent by a single optic nerve fibre when the receptors connected to it are stimulated by light. He found that the receptor cells in the eye are interconnected in such a way that when one is stimulated, others nearby are depressed, thus enhancing the contrast in light patterns and sharpening the perception of shapes. Hartline thus built up a detailed understanding of the workings of individual photoreceptors and nerve fibres in the retina, and he showed how simple retinal mechanisms constitute vital steps in the integration of visual information.* * *
Universalium. 2010.
