/tol byooh"teuh muyd'/, n. Pharm.
a white crystalline substance, C12H18N2O3S, used to augment insulin secretion in the treatment of diabetes mellitus.
[1955-60; TOL(U) + BUT(YL) + AMIDE]

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      drug used in the treatment of type II (non-insulin-dependent) diabetes (diabetes mellitus). Tolbutamide stimulates the release of insulin from the pancreas, thereby reducing the concentration of glucose in the blood.

      Tolbutamide is one of a class of compounds called sulfonylureas and was the first agent of this type to be widely administered. Though discovered in the 1940s, sulfonylureas were not used until the mid-1950s to control type II diabetes. Tolbutamide is used to treat patients with mild to moderate diabetes that cannot be controlled by diet alone. It is quickly metabolized and is usually administered in divided doses. The drug has been associated with an increased mortality due to cardiovascular disease.

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Universalium. 2010.

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Look at other dictionaries:

  • Tolbutamide — Systematic (IUPAC) name N [(butylamino)carbonyl] 4 methylbenzenesulfonamide Clinical data AHFS/ …   Wikipedia

  • tolbutamide — [ tɔlbytamid ] n. m. • v. 1960; de tol(yle), but(yle) et amide ♦ Méd. Sulfamide administré par voie buccale dans le traitement du diabète. ● tolbutamide ou tolglybutamide nom masculin Dénomination courante d un sulfamide hypoglycémiant …   Encyclopédie Universelle

  • tolbutamide — ☆ tolbutamide [täl byo͞ot′ə mīd΄ ] n. [ TOL(U) + BUT(YRIC) + AMIDE] an oral drug, C12H18N2O3S, that stimulates the pancreas to secrete more insulin, used to treat diabetes …   English World dictionary

  • tolbutamide sodium — the monosodium salt of tolbutamide, having the same actions as the base; used as a diagnostic test for insulinoma (tolbutamide test, q.v.) and for diabetes mellitus and other pancreatic disorders, administered intravenously …   Medical dictionary

  • tolbutamide test — (for insulinoma) one gram of tolbutamide is administered intravenously and plasma levels of glucose and insulin are monitored for 3 hours; prolonged hypoglycemia with hyperinsulinemia indicates presence of an insulinoma …   Medical dictionary

  • tolbutamide — noun Etymology: tol + butyric + amide Date: 1956 a sulfonylurea C12H18N2O3S used in the treatment of diabetes …   New Collegiate Dictionary

  • tolbutamide — A sulphonylurea that will bind to SUR and enhance insulin release from pancreatic B cells. Used in Type II diabetes (as are a number of similar drugs) …   Dictionary of molecular biology

  • tolbutamide — noun A drug that blocks potassium channels, used in the treatment of diabetes …   Wiktionary

  • tolbutamide — An orally active hypoglycemic agent used in the management of adult onset diabetes mellitus; it appears to stimulate the synthesis and release of endogenous insulin from functional islets; available as t. sodium for injection. * * *… …   Medical dictionary

  • tolbutamide — tol·bu·ta·mide …   English syllables

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