/ree"nin/, n. Biochem.
a proteolytic enzyme secreted by the kidneys that is involved in the release of angiotensin.
[1890-95; REN(I)- + -IN2]

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      enzyme secreted by the kidney (and also, possibly, by the placenta) that breaks down protein and produces a rise in blood pressure. In the blood, renin acts on a fraction of the plasma proteins and releases angiotensin I. Angiotensin II is formed by the action of converting enzyme, which splits off two amino acids from the 10-amino-acid chain of angiotensin I. The resultant octapeptide (previously called hypertensin, or angiotonin) constricts arterioles, causing a rise in both systolic and diastolic blood pressure. It is one of the most active vasoconstrictors known; on a weight basis it is about six times as potent as norepinephrine. It also increases the secretion of cortisol and aldosterone by a direct action on the adrenal cortex.

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Universalium. 2010.

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  • renin — 1894, from L. renes “kidneys” + in …   Etymology dictionary

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  • renin — A term originally used for a pressor substance obtained from rabbits kidneys, now an enzyme that converts angiotensinogen to angiotensin I. SYN: angiotensinogenase. * * * re·nin rē nənalso ren ən n a proteolytic enzyme of the blood that is… …   Medical dictionary

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