/proh jear"ee euh/, n. Pathol.
a rare congenital abnormality characterized by premature and rapid aging, the affected individual appearing in childhood as an aged person and having a shortened life span.
[1900-05; < NL < Gk progér(os) prematurely old (pro- PRO-2 + gêr(as) old age + -os adj. suffix) + NL -ia -IA]

* * *

Disorder with characteristics of premature aging.

Affected persons have thin skin, go bald or gray early, and develop diseases of aging decades earlier than normal individuals. Not all systems are affected; there is no senility, no aging in the central nervous system. There are two major types. In the extremely rare Hutchinson-Gilford syndrome, children look 60 years old by age 10 and die at an average age of 13. The unrelated Werner syndrome is a recessive hereditary disease that begins in young adulthood and makes patients look 30 years older than they are; their average life span is 47 years.

* * *

      human disorder with many characteristics of premature aging (human aging). Affected persons have parchment-like skin, become bald or gray-haired early in life, and tend to develop diseases related to aging decades before they occur in normal individuals. Initially, progeria was studied as a model of normal aging, but because not all organs are affected, this is no longer thought to be appropriate. There is, for example, no evidence of senility or of aging in the central nervous system. Two major types of progeria occur: the extremely rare Hutchinson–Gilford syndrome, which has its onset in early childhood, and Werner's syndrome, which is unrelated and occurs later in life. A third disease, progeria with microphthalmia (the Hallerman–Streiff–François syndrome), in which dwarfism is a prominent feature, is also sometimes included.

      Signs of infant progeria, the Hutchinson–Gilford syndrome, appear at about age one, after an evidently normal infancy. Affected individuals seldom exceed the size of a normal 5-year-old, although they have the physical appearance of 60-year-old adults by the time they are 10. Many of the superficial aspects of aging, such as baldness, thinning of the skin, prominence of blood vessels of the scalp, and vascular diseases, occur. Sex organs remain small and underdeveloped. A few individuals with progeria are mentally retarded, but most have normal intelligence and may even be precocious. By age 10, extensive arteriosclerosis and heart disease have developed, and most patients die before they reach 30; the median age of death is 13. A hereditary basis has been suspected, but there is no evidence to support the suspicion, and the cause remains a mystery.

      Werner's syndrome, sometimes called progeria of the adult, appears in young adulthood or, less commonly, in late adolescence. The aging changes are somewhat less pronounced, so that affected persons look about 30 years older than their chronological age. There is no dwarfism, as growth has been completed by the time the disease appears, but affected persons tend to be slightly shorter than average. Patients with Werner's syndrome are sexually mature, but secondary sex characteristics are poorly developed. Superficial signs of aging are premature balding or graying of hair, loss of teeth and hearing, cataracts, acute arthritic episodes, skin ulcers, and osteoporosis (loss of bony tissue). There is an increased tendency to develop heart disease, diabetes mellitus, and cancer, and the average lifespan is 47 years. This type of progeria is hereditary and is transmitted as a recessive trait, but its underlying cause is unknown.

* * *

Universalium. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Progeria — Progéria Enfant atteint de progéria (l image en haut à droite représente un noyau cellulaire normal, celui d en bas, un noyau déformé au cours d une progéria). La progéria, ou Syndrome de Hutchinson Gilford, est une maladie génétique extrêmement… …   Wikipédia en Français

  • Progeria — Niño con Sindrome de Progeria Clasificación y recursos externos CIE 10 …   Wikipedia Español

  • progeria — f. patol. Enfermedad hereditaria poco frecuente que se caracteriza por un envejecimiento precoz y muy acelerado del sujeto afectado. La senilidad se inicia desde muy pronto y enseguida el niño empieza a mostrar los primeros síntomas: piel… …   Diccionario médico

  • Progeria — progeria. f. Med. Síndrome genético que consiste en un envejecimiento prematuro. * * * Progeria (del griego geras, vejez) es una extremadamente rara enfermedad genética de la infancia caracterizada por un dramático envejecimiento prematuro. Se… …   Enciclopedia Universal

  • progeria — 1904, Modern Latin, from Gk. progeros prematurely old; see PRO (Cf. pro ) + GERIATRIC (Cf. geriatric) …   Etymology dictionary

  • progéria — s. f. [Medicina] Doença genética que se caracteriza por envelhecimento precoce e, nas crianças, nanismo.   ‣ Etimologia: grego progeros, on, prematuramente velho + ia …   Dicionário da Língua Portuguesa

  • progeria — f. Med. Síndrome genético que consiste en un envejecimiento prematuro …   Diccionario de la lengua española

  • progeria — [prō jir′ē ə] n. [ModL < Gr progērōs, prematurely old < pro, before + gēras, old age + IA] a rare genetic disorder, esp. of early childhood, characterized by premature aging …   English World dictionary

  • Progeria — Infobox Disease Name = Progeria Caption = DiseasesDB = 10704 ICD10 = ICD10|E|34|8|e|20 ICD9 = ICD9|259.8 ICDO = OMIM = 176670 MedlinePlus = eMedicineSubj = derm eMedicineTopic = 731 MeshID = D011371 Progeria is a condition of early aging [Stedman …   Wikipedia

  • Progéria — Enfant atteint de progéria (l image en haut à droite représente un noyau cellulaire normal, celui d en bas, un noyau déformé au cours d une progéria). La progéria, ou Syndrome de Hutchinson Gilford, est une maladie génétique extrêmement rare …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”