/proh ben"euh sid/, n. Pharm.
a white, crystalline, water-insoluble powder, C13H19NO4S, used chiefly in the treatment of gout.
[1945-50; PRO(PYL) + BEN(ZEN)E + (A)CID]

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      drug used in the treatment of chronic gout, a disorder that is characterized by recurrent acute attacks of inflammation in one or more joints of the extremities. Probenecid inhibits the transport of most organic acids in the renal tubules of the kidneys. It was used in medicine originally to prolong the action of the antibiotic penicillin by preventing its loss in the urine. In large doses, however, probenecid enhances the excretion of uric acid, the compound that accumulates in and about the joints in persons with gout. Continued administration of the drug in gouty arthritis shrinks solid uric acid deposits in the joints and reduces swelling in enlarged joints, thus restoring their mobility.

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Universalium. 2010.

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Look at other dictionaries:

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  • probenecid — Uricosúrico y coadyuvante de los antibióticos. Se prescribe para el tratamiento de la gota y como coadyuvante para prolongar la actividad de la penicilina o de las cefalosporinas en algunas infecciones, como la gonorrea …   Diccionario médico

  • probenecid — [prō ben′ə sid] n. a white, crystalline drug, C13H19NO4S, that influences the ability of the kidney to separate various compounds from the blood, used to increase the urinary excretion of uric acid in cases of gout and to decrease the urinary… …   English World dictionary

  • Probenecid — Strukturformel Allgemeines Freiname Probenecid Andere Namen …   Deutsch Wikipedia

  • Probenecid and colchicine — are a combination of drugs used to treat gout. v · …   Wikipedia

  • probenecid — noun Etymology: irregular from propyl + benzoic acid Date: 1950 a drug C13H19NO4S that acts on renal tubular function and is used to increase the concentration of some drugs (as penicillin) in the blood by inhibiting their excretion and to… …   New Collegiate Dictionary

  • probenecid — noun A particular pharmaceutical drug used to treat hyperuricemia …   Wiktionary

  • probenecid — A competitive inhibitor of the secretion of penicillin or p aminohippurate by kidney tubules; a uricosuric agent used in chronic gouty arthritis. * * * pro·ben·e·cid prō ben ə səd n a drug C13H19 …   Medical dictionary

  • probenecid — n. drug used to treat arthritis …   English contemporary dictionary

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