polio

/poh"lee oh'/, n.

poliomyelitis.

[1930-35, Amer.; shortened form]

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▪ pathology

Introduction

in full  poliomyelitis , also called  infantile paralysis 

 acute viral infectious disease of the nervous system that usually begins with general symptoms such as fever, headache, nausea, fatigue, and muscle pains and spasms and is sometimes followed by a more serious and permanent paralysis of muscles (muscle disease) in one or more limbs, the throat, or the chest. More than half of all cases of polio occur in children (childhood disease and disorder) under the age of five. The paralysis so commonly associated with the disease actually affects fewer than 1 percent of persons infected by the poliovirus. Between 5 and 10 percent of infected persons display only the general symptoms outlined above, and more than 90 percent show no signs of illness at all. For those infected by the poliovirus, there is no cure, and in the mid-20th century hundreds of thousands of children were struck by the disease every year. Since the 1960s, thanks to widespread use of polio vaccines, polio has been eliminated from most of the world, and it is now endemic only in several countries of Africa and South Asia. Approximately 1,000–2,000 children are still paralyzed by polio each year, most of them in India.

The course of the disease

      Poliomyelitis means “gray marrow inflammation,” referring to the propensity of the poliovirus to attack certain cells in the spinal cord and brainstem. The poliovirus is a picornavirus (family Picornaviridae), a member of a group known as enteroviruses that inhabits the human digestive tract. (Human beings are the only known hosts of the poliovirus.) The virus enters the body most often by the so-called fecal–oral route—that is, from fecal matter taken into the mouth through contaminated food or fingers. It can also enter by ingestion of droplets expelled from the throat of an infected person. New victims may become ill about 7 to 14 days after ingesting the virus. Infected persons may shed the virus from their throats for a week, beginning a day or more before suffering any symptoms themselves, and they may continue to shed the virus in their feces for a month or more after their illness.

      After the poliovirus is swallowed, it multiplies in lymph nodes of the intestinal tract and spreads through the body via the bloodstream. In some people the virus gets no farther, causing only a vague flulike illness to develop. The most common early symptoms of polio are mild headache, fever, sore throat, nausea, vomiting, diarrhea, restlessness, and drowsiness. Fever peaks in two to three days and then rapidly subsides, and patients recover within three to four days without the development of paralysis.

      In some cases, however, the virus begins an assault on the central nervous system, inflaming and destroying motor cells of the spinal cord and brainstem. In these cases, patients become irritable and develop pain in the back and limbs, muscle tenderness, and stiff neck. Many recover at this stage, but approximately 1 in 200 persons with polio develops what is known as flaccid paralysis. The motor impulses that normally move along the nerve fibres from the spinal cord to muscles are blocked, and, as a result, muscles become limp and cannot contract. The extent of paralysis depends on where the virus strikes and the number of nerve cells that it destroys. Cells that are not severely injured recover their normal function in time; to the extent that they do recover, a corresponding restoration of muscle function may be expected. Cells that are destroyed, however, are not replaced, because nerve cells cannot regenerate. In this case the paralysis is complete and permanent, with associated progressive atrophy of the unused muscles.

 In most cases paralytic polio strikes the limb muscles, particularly the legs. Paralysis does not always involve the limbs, however. The abdominal muscles or the muscles of the back may be paralyzed, affecting posture. The neck muscles may become weak, so that the head cannot be raised. Paralysis of the face muscles may cause twisting of the mouth or drooping eyelids. In some types of spinal polio, the virus damages the upper part of the spinal cord, with resulting difficulties in breathing. In bulbar polio the virus attacks the brainstem, and the nerve centres that control swallowing and talking are damaged. Secretions collect in the throat and may lead to suffocation by blocking the airway. Some 5 to 10 percent of persons afflicted with paralytic polio die, usually of respiratory complications.

      There seem to be individual differences in the degree of natural susceptibility to the disease. Many persons have acquired antibodies to the poliovirus in their blood without having had any symptoms of infection. It is generally held that a lasting immunity follows recovery from the disease. However, because there are three different serotypes of poliovirus—commonly called types I, II, and III—second attacks can occur. Persons who recover from an infection caused by one type of poliovirus are permanently immune to reinfection by that type but not to infection by the other types. For this reason polio vaccines are trivalent—that is, designed to generate antibodies to all three poliovirus types (see below).

      Among as many as one-quarter of former polio victims whose condition has been stabilized for years or even decades, a condition called post-polio syndrome has been recognized. Post-polio syndrome manifests itself as increased weakness, muscle atrophy, or other conditions involving the originally affected muscle groups or a different group of muscles. The cause of the syndrome is not known for certain, but it may arise when nerve branches grown by nerve fibres that survived the original infection begin to deteriorate as the former polio victim passes through middle age. There is no cure for post-polio syndrome.

Treatment and vaccination

      Treatment during the preparalytic stages of polio includes complete bed rest, isolation, and careful observation. If paralysis occurs, passive movement of the limbs can be used to avoid deformities. As muscle strength returns, exercises are increased. Breathing may require mechanical aids such as the positive pressure ventilator, which pumps air into the patient's lungs through an endotracheal tube inserted into the windpipe. Ventilators have largely replaced the “iron lungs” that gave polio such a dreadful image during the 20th century. Formally known as tank respirators, iron lungs were large steel cylinders that enclosed the abdomen or the entire body (except for the head) of a patient lying immobilized on a bed. Through the action of an attached bellows, air pressure inside the cylinder was alternately reduced and restored, forcing the paralyzed patient's lungs to expand and contract.

      There are two types of polio vaccine: the inactivated poliovirus vaccine (IPV), also known as the Salk vaccine after its inventor, Jonas Salk (Salk, Jonas Edward); and the oral poliovirus vaccine (OPV), or Sabin vaccine, named for its inventor, Albert Sabin (Sabin, Albert Bruce). IPV, based on killed, or inactivated, poliovirus types I, II, and III, was the first vaccine to break the scourge of polio epidemics in the 1950s. It is administered by injection and circulates through the bloodstream, where it causes the generation of antibodies against active, or “wild” (as opposed to vaccine-type), virus. OPV is based on live but weakened, or attenuated, poliovirus. There are two types of OPV: trivalent (tOPV), which contains all three types of live attenuated polioviruses; and monovalent (mOPV), which contains one of the three types of live attenuated polioviruses. Thus, trivalent vaccine is effective against all three types of poliovirus, and monovalent vaccines are effective against a single type of poliovirus. The specificity of mOPVs increases their effectiveness, such that a single dose of mOPV1, which is effective only against poliovirus type I, confers immunity to type I virus in roughly 70 to 80 percent of children, whereas a single dose of tOPV confers immunity to type I virus in about 20 to 40 percent of children.

      OPV is administered by drops in the mouth. After the vaccine is swallowed, the attenuated virus multiplies in the small intestine and lymph nodes and causes the generation of antibodies against wild virus. It is also shed through the inoculated person's feces, thus indirectly immunizing other people through the fecal-oral route. OPV became the predominant vaccine after it was introduced in the early 1960s. Both vaccines are given three times, preferably in the first few months of an infant's life and then usually once as a “booster” when the child reaches school age. With these four doses, immunity against polio is almost completely assured.

      In rare cases, OPV can give rise to vaccine-derived polioviruses (VDPVs), which are mutated strains of the live attenuated virus contained in the vaccine. There are several different types of VDPVs, including circulating vaccine-derived viruses (cVDPVs), which cause paralysis and occur within populations that have low polio-immunization rates. OPV has also been known to cause rare cases of what is known as vaccine-associated paralytic polio (VAPP) in both vaccine recipients and their contacts. Such cases occur once in every two million or more doses of OPV. VAPP appears to be caused by a reversion mutation of attenuated virus, thereby converting the virus back to an infectious form that subsequently attacks the nervous system. VAPP is more likely to arise in persons whose immune systems are deficient. Because of this risk, OPV was dropped from immunization programs in the United States in 2000 in favour of IPV. However, OPV, particularly mOPV1, which was found to be four times more effective in children than other polio vaccines, continued to be used in countries such as Nigeria, where polio remained a significant problem in the early 21st century.

Polio through history

From minor outbreaks to epidemics

      Polio epidemics (epidemic) did not begin to occur until the latter part of the 19th century, but evidence indicates that it is an ancient disease. A well-known stele from the 18th dynasty of ancient Egypt (1570–1342 BC) clearly depicts a priest with a telltale paralysis and withering of his lower right leg and foot. The mummy of the pharaoh Siptah from the late 19th dynasty (1342–1197 BC) shows a similarly characteristic deformity of the left leg and foot. However, owing to the sporadic appearance of the infection, the absence of epidemics until relatively recent times, and the nonspecific nature and infrequency of the acute illness, there is hardly another recognizable trace of the disease until the 18th century. In 1789 a pediatrician in London, Michael Underwood, published the first clear description of paralytic disease of infants in a medical textbook. In the early 19th century, small groups of polio-afflicted patients began to be reported in the medical literature, but still only as sporadic cases.

      It is an irony of medical history that the transformation of polio into an epidemic disease occurred only in those industrialized countries in North America and Europe that had experienced significant improvements in hygiene during the 19th and 20th centuries. This has led health experts to conjecture that the infection was common in earlier times but that people were exposed and infected (in typically unhygienic environments) at very young ages, when they were less likely to suffer permanent paralysis as an outcome. As hygiene improved, the certainty of young people of successive generations being exposed to the virus was gradually reduced; in this new situation it was not long before enough susceptible children and adults had accumulated to allow epidemics to break out.

      The first epidemics appeared in the form of outbreaks of at least 14 cases near Oslo, Norway, in 1868 and of 13 cases in northern Sweden in 1881. About the same time the idea began to be suggested that the hitherto sporadic cases of infantile paralysis might be contagious. The next significant epidemic, 10 times larger than previous outbreaks, with 132 recognized cases, erupted in the U.S. state of Vermont in 1894. During an epidemic of 1,031 cases in Sweden in 1905, Ivar Wickman recognized that patients with nonparalytic disease could spread the virus, and during an epidemic of 3,840 cases in 1911, Carl Kling and colleagues in Stockholm recovered the virus from healthy carriers as well as paralytic patients. In studying several fatal cases from the same outbreak, Kling found the virus in the victims' throats and also in tissues of their small intestines. During the second decade of the 20th century, it became apparent that far more people were being rendered immune to polio by previous asymptomatic infections than were being immunized by recovery from overt disease. By then polio was well on the way to becoming a widely feared periodic phenomenon. In the 1940s and early 1950s, western Europe and North America lived through summertime terrors brought about by nearly annual polio epidemics. At its peak incidence in the United States, in 1952, approximately 21,000 cases of paralytic polio (a rate of 13.6 cases per 100,000 population) were recorded. As outbreaks were concentrated in the summer and early autumn, children were kept away from swimming pools, movie theatres, and other crowded places where they might be exposed to the dreaded virus. Outbreaks were widely reported in the press, and polio victims encased in iron lungs were often displayed in public places such as department stores in order to encourage donations to efforts to research and combat the disease. In such an environment, it is not surprising that the announcement of an effective vaccine in 1955 was hailed as a mid-20th-century miracle.

The age of the vaccine

      The poliovirus itself was discovered in 1908 by a team led by Viennese immunologist and future Nobel Prize winner Karl Landsteiner (Landsteiner, Karl). The existence of telltale antibodies specific to the virus circulating in the blood of infected persons was discovered only two years later. In 1931 two Australian researchers, Frank Macfarlane Burnet (Burnet, Sir Macfarlane) and Jean Macnamara, using immunologic techniques, were able to identify the different serotypes of the poliovirus. (Burnet was to receive a Nobel Prize in 1960.) In 1948 the team of John Enders (Enders, John Franklin), Thomas Weller (Weller, Thomas H.), and Frederick Robbins (Robbins, Frederick Chapman), working at Harvard Medical School in Massachusetts, showed how the virus could be grown in large amounts in tissue culture (an advance for which they shared a Nobel Prize in 1954). From there it was only a short step to an announcement in 1953 by Jonas Salk (Salk, Jonas Edward) at the University of Pittsburgh, Pennsylvania, that he had developed an effective killed-virus vaccine.

 Salk's vaccine, known as the inactivated poliovirus vaccine (IPV), was put to a massive nationwide test in 1954–55. Called the Francis Field Trial after Thomas Francis, Jr., a University of Michigan professor who directed it, the test involved 1.8 million children in the first, second, and third grades across the United States. The trial was declared a success on April 12, 1955, and over the next four years more than 450 million doses of the Salk vaccine were distributed. During that time the incidence of paralytic polio in the United States fell from 18 cases per 100,000 population to fewer than 2 per 100,000. In the years 1961–63, approval was given to a new vaccine developed by Albert Sabin (Sabin, Albert Bruce) at the University of Cincinnati, Ohio. The Sabin vaccine, using live but attenuated virus, could be given in drops through the mouth and therefore became known as the oral poliovirus vaccine (OPV). Soon it became the predominant vaccine used in the United States and most other countries. By the early 1970s the annual incidence of polio in the United States had declined a thousandfold from prevaccine levels, to an average of 12 cases a year.

      This progress was mirrored in other industrialized countries. Canada, having suffered its worst outbreak in 1953 (almost 9,000 cases of all types of polio), quickly began production of the Salk and Sabin vaccines, and in 1965 only three cases of polio were reported. Finland began limited vaccination with the Salk vaccine in 1957 following two major outbreaks in 1954 and 1956. Some 1.5 million persons were vaccinated in a mass campaign in 1960–61, which eliminated the disease altogether in that country. Belgium began using the Salk vaccine in 1958 and the Sabin vaccine in 1963; as a result, polio disappeared as an endemic disease in the late 1960s. Denmark introduced IPV to its population in 1955 and OPV in 1963 and experienced only sporadic cases of the disease after 1962.

A global campaign

      Even as the introduction of vaccines led inexorably to the decline and eventual disappearance of polio in the developed countries of the temperate world, only some 5 percent of schoolchildren were being routinely immunized in the less-developed countries of the tropics, where the disease was not considered to be a problem. However, when “lameness surveys” were conducted during the 1970s in several tropical countries, it was learned to considerable surprise that from 5 to 9 of every 1,000 schoolchildren had evidence of lameness due to paralytic polio. Immunization against polio was included in the Expanded Program on Immunization, launched by the World Health Organization (WHO) in 1974, and by 1989 the proportion of children being immunized rose to some 67 percent.

      In 1985 the Pan American Health Organization, WHO's regional body for the Americas, announced an initiative to eradicate indigenous transmission of polio from that part of the world by the end of 1990. This followed not only the success of the United States and Canada in eliminating the disease but also successes in Brazil and Cuba, among other countries. Cuba began mass immunizations in 1962 and brought the number of cases down from 214 per year in the 1950s to a total of 5 cases between 1963 and 1978. Brazil began an immunization campaign in 1980; the reported cases there dropped from an average of 2,330 per year in the late 1970s to 69 cases in 1982. In 1994 all of the Western Hemisphere was declared free of indigenous polio.

      Progress in the Americas was a major factor in the decision by WHO's World Health Assembly in 1988 to call for the eradication of polio from the globe by the year 2000. The Global Polio Eradication Initiative was joined by UNICEF, Rotary International, and other organizations, and by 2000 the number of new cases of paralytic polio had been reduced from more than 250,000 per year to approximately 1,000–2,000. Complete elimination of the disease by the target year was not possible, given the complexity of storing and distributing the vaccine, the disruption of record keeping in countries plagued by poverty and conflict, and suspicion and resistance on the part of some local leaders. Nevertheless, polio as an endemic disease had been limited to a handful of countries in Africa and South Asia, though travelers from these countries frequently exported cases to other countries.

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