pepsin

/pep"sin/, n. Biochem.

1. an enzyme, produced in the stomach, that in the presence of hydrochloric acid splits proteins into proteoses and peptones.

2. a commercial form of this substance, obtained from the stomachs of hogs, used as a digestive, as a ferment in the manufacture of cheese, etc.

Also, pepsine.

[1835-45; < Gk péps(is) digestion (pep-, base of péptein to digest + -sis -SIS) + -IN²]

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Powerful enzyme in gastric juice (see stomach) that partially digests proteins in food.

Glands in the stomach lining make pepsinogen, a zymogen (enzyme precursor) converted to pepsin by the hydrochloric acid in gastric juice. Pepsin is active only in the acid environment of the stomach (pH 1.5–2.5 or less); it is ineffective in the intestine (pH 7, neutral). It is used commercially in some cheese making, in the leather industry to remove hair and residual tissue from hides, and in the recovery of silver from discarded photographic films by digesting the gelatin layer that holds the silver.

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▪ biochemistry

 the powerful enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, or dairy products.

      Pepsin was first recognized in 1836 by the German physiologist Theodor Schwann. In 1930 it was crystallized and its protein nature established by John H. Northrop of the Rockefeller Institute for Medical Research.

      Glands in the mucous-membrane lining of the stomach make and store an inactive protein called pepsinogen. Impulses from the vagus nerve and the hormonal secretions of gastrin and secretin stimulate the release of pepsinogen into the stomach, where it is mixed with hydrochloric acid and rapidly converted to the active enzyme pepsin. The digestive power of pepsin is greatest at the acidity of normal gastric juice (pH 1.5–2.5). In the intestine the gastric acids are neutralized (pH 7), and pepsin is no longer effective.

      In the digestive tract pepsin effects only partial degradation of proteins into smaller units called peptides, which then either are absorbed from the intestine into the bloodstream or are broken down further by pancreatic enzymes.

      Small amounts of pepsin pass from the stomach into the bloodstream, where it breaks down some of the larger, or still partially undigested, fragments of protein that may have been absorbed by the small intestine.

      Pepsin is prepared commercially from swine stomachs. Crude pepsin is used in the leather industry to remove hair and residual tissue from animal hides prior to their being tanned. It is also used in the recovery of silver from discarded photographic films by digesting the gelatin layer that holds the silver compound.

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