fibrous dysplasia

fibrous dysplasia

      rare congenital developmental disorder beginning in childhood and characterized by replacement of solid calcified bone with fibrous tissue, often only on one side of the body and primarily in the long bones and pelvis. One bone (monostotic) or several bones (polystotic) may be affected. The disease appears to result from a genetic mutation that leads to the overproduction of fibrous tissue. Manifestations of the disorder include enlargement of the bones on one side of the face and base of the skull, bone pain, and a tendency to fractures (fracture). Individuals with fibrous dysplasia who exhibit café au lait (pale brown) spots on the skin and endocrine imbalance leading to precocious puberty, especially in girls, have a form of the disorder called McCune-Albright syndrome. Orthopedic surgery may be necessary for disability resulting from fractures and bony overgrowth.

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Universalium. 2010.

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Look at other dictionaries:

  • fibrous dysplasia — a developmental abnormality in which changes occur in bony tissue. Trabecular bone is replaced by fibrous tissue, resulting in aching and a tendency to pathological fracture. In monostotic fibrous dysplasia one bone is affected; polyostotic… …   Medical dictionary

  • fibrous dysplasia — a developmental abnormality in which changes occur in bony tissue. Trabecular bone is replaced by fibrous tissue, resulting in aching and a tendency to pathological fracture. In monostotic fibrous dysplasia one bone is affected; polyostotic… …   The new mediacal dictionary

  • Fibrous dysplasia of bone — DiseaseDisorder infobox Name = Fibrous dysplasia ICD10 = ICD10|K|10|8|k|00, ICD10|M|85|0|m|80, ICD10|Q|78|1|q|65 ICD9 = ICD9|526.89, ICD9|733.29, ICD9|756.54 ICDO = Caption = OMIM = MedlinePlus = 001234 eMedicineSubj = radio eMedicineTopic = 284… …   Wikipedia

  • fibrous dysplasia of bone — noun a disturbance in which bone that is undergoing lysis is replaced by an abnormal proliferation of fibrous tissue resulting in bone lesions or skin lesions • Hypernyms: ↑dysplasia • Hyponyms: ↑Albright s disease, ↑polyostotic fibrous dysplasia …   Useful english dictionary

  • Fibrous dysplasia, polyostotic — A genetic disorder of bones, skin pigmentation and hormonal problems with premature sexual development. Also called McCune Albright syndrome or the Albright syndrome. In the syndrome, there is bone disease with fractures and deformity of the legs …   Medical dictionary

  • fibrous dysplasia — noun The replacement of an area of bone by fibrous tissue; often linked with premature sexual development as part of a syndrome …   Wiktionary

  • monostotic fibrous dysplasia — fibrous dysplasia of bone involving only one bone. Called also osteitis fibrosa localisata …   Medical dictionary

  • fibrous dysplasia of bone — a disease of bone marked by thinning of the cortex and replacement of bone marrow by gritty fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Two types or stages are distinguished: monostotic …   Medical dictionary

  • Fibrous dysplasia, monostotic — Excessive growth of hard fibrous tissue that replaces normal bone tissue in a single bone. Symptoms may include pain and fracture of the bone. Most cases are diagnosed in adolescence and young adulthood and remain unchanged throughout life. The… …   Medical dictionary

  • Monostotic fibrous dysplasia — Classification and external resources ICD 10 M85.0 ICD 9 733.29 …   Wikipedia

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