Huggins, Charles Brenton

Huggins, Charles Brenton
▪ 1998

      Canadian-born American surgeon and medical researcher (b. Sept. 22, 1901, Halifax, N.S.—d. Jan. 12, 1997, Chicago, Ill.), specialized in the surgical and therapeutic treatment of cancer of the prostate and mammary glands and shared (with Peyton Rous) the 1966 Nobel Prize for Physiology or Medicine for discovering the influence that hormones have on the onset and growth of certain forms of human cancer. His work demonstrated that cancer cells are not necessarily autonomous and self-perpetuating and that some depend on chemical signals such as hormones to survive. This insight led to the development of hormone therapy as a treatment for endocrine-dependent tumours. Huggins graduated from Harvard Medical School (M.D., 1924) and began his career as a surgeon at the University of Michigan. In 1927 he joined the faculty of the University of Chicago, where he founded and served as director (1951-69) of the university's Ben May Laboratory for Cancer Research. Although initially involved in urology research, in the early 1930s Huggins became intrigued by discoveries being made in the field of cancer research by the German biochemist Otto Warburg, who won a Nobel Prize in 1931. Through his own research, Huggins discovered that the growth of prostate cancer could be stemmed by lowering levels of androgens, the male sex hormones, either by removal of the testes or by administration of real or synthetic female sex hormones. In 1944, recognizing that the adrenal glands were compensating for the loss of androgens in some treated patients whose prostate cancer recurred, Huggins performed the first complete removal of the adrenal glands, although this was considered a radical treatment to be used only as a last resort. Huggins turned his attention to breast cancer in the 1950s and showed that removal of the ovaries and adrenal glands combined with cortisone-replacement therapy was beneficial to 30-40% of women who were treated. His work led to the development of a test to distinguish between two types of breast cancer—one that was hormone-dependent and the other not—that helped determine which patients would benefit from this treatment. Huggins became involved in the 1960s controversy over whether birth control pills stimulated the growth of cancer of the breast and reproductive organs, and he maintained that data collected from thousands of patients did not support this link. Huggins received a number of honours, including the Lasker Award for Clinical Research in 1963. He was also the author of several books, notably Experimental Leukemia and Mammary Cancer: Induction, Prevention, Cure (1979).

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Universalium. 2010.

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  • Huggins,Charles Brenton — Hug·gins (hŭgʹĭnz), Charles Brenton. 1901 1997. Canadian born American surgeon. He shared a 1966 Nobel Prize for research in hormone treatment for cancer of the prostate. * * * …   Universalium

  • Huggins , Charles Brenton — (1901–) Canadian–American surgeon Huggins, who was born at Halifax in Nova Scotia, was educated at Acadia University and at the Harvard Medical School, where he obtained his MD in 1924. After graduate training at the University of Michigan he… …   Scientists

  • Charles Brenton Huggins — Born September 22, 1901 …   Wikipedia

  • Charles Brenton Huggins — Pour les articles homonymes, voir Huggins. Charles Brenton Huggins (22 septembre 1901 à Halifax, Nouvelle Écosse, Canada 12 janvier 1997 à Chicago) est un physiologiste américain, natif du Canada. Chercheur spécialiste du… …   Wikipédia en Français

  • Charles Brenton Huggins — (* 22. September 1901 in Halifax, Kanada; † 12. Januar 1997 in Chicago, USA) war ein kanadisch US amerikanischer Chirurg. Er erhielt 1963 den Albert Lasker Award for Clinical Medical Research und 1966 den Nobelpreis für Physiologie oder Medizin… …   Deutsch Wikipedia

  • Charles Brenton Huggins — Dr. Charles Brenton Huggins ( * 22 de septiembre de 1901 – 12 de enero de 1997) fue un médico, fisiólogo e investigador de cáncer estadounidense nacido en Canadá. Investigador de la Universidad de Chicago especializado en cáncer de próstata. Él y …   Wikipedia Español

  • Huggins, Charles B. — ▪ American surgeon and medical researcher in full  Charles Brenton Huggins   born Sept. 22, 1901, Halifax, Nova Scotia, Can. died Jan. 12, 1997, Chicago, Ill., U.S.  Canadian born American surgeon and urologist whose investigations demonstrated… …   Universalium

  • Charles Brenton Huggins — n. Charles Huggins (1901 1997), Canadian born American physiologist and surgeon and cancer researcher who won the Nobel Prize for Physiology or Medicine in 1966 (together with Peyton Rous) for his discovery that hormones could be used to control… …   English contemporary dictionary

  • Medizinnobelpreis 1966: Charles Brenton Huggins — Francis Peyton Rous —   Rous erhielt den Nobelpreis für »seine Entdeckung zu Tumoren erzeugenden Viren« und Huggins für »Entdeckungen zur Hormonbehandlung von Prostatakrebs«.    Biografien   Charles Brenton Huggins, * Halifax (Kanada) 22. 9. 1901, ✝ Chicago 12. 1.… …   Universal-Lexikon

  • Charles B. Huggins — Charles Brenton Huggins (* 22. September 1901 in Halifax, Kanada; † 12. Januar 1997 in Chicago, USA) war ein kanadisch US amerikanischer Chirurg. Er erhielt 1966 den Nobelpreis für Physiologie oder Medizin für seine „Entdeckungen zur… …   Deutsch Wikipedia

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