feedback inhibition

feedback inhibition
Suppression of the activity of an enzyme by a product of the sequence of reactions in which the enzyme is participating.

When the product accumulates in a cell beyond an optimal amount, it decreases its own production by inhibiting an enzyme involved in its synthesis. After the product has been used or broken down, inhibition is relaxed and formation of the product resumes. Enzymes whose ability to catalyze a reaction depends on molecules other than the substances on which they act directly are said to be under allosteric control.

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      in enzymology, suppression of the activity of an enzyme, participating in a sequence of reactions by which a substance is synthesized, by a product of that sequence. When the product accumulates in a cell beyond an optimal amount, its production is decreased by inhibition of an enzyme involved in its synthesis. After the product has been utilized or broken down and its concentration thus decreased, the inhibition is relaxed, and the formation of the product resumes. Such enzymes, whose ability to catalyze a reaction depends upon molecules other than their substrates (the ones upon which they act to form a product), are said to be under allosteric control. Feedback inhibition is a mechanism by which the concentration of certain cell constituents is limited.

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Universalium. 2010.

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Look at other dictionaries:

  • feedback inhibition — n inhibition of an enzyme controlling an early stage of a series of biochemical reactions by the end product when it reaches a critical concentration * * * inhibition of the initial steps of a process by an endproduct of the reaction …   Medical dictionary

  • feedback inhibition — feedback inhibition. = end product inhibition (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • feedback inhibition — feedback inhibition. См. ретроингибирование. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • feedback inhibition — noun : inhibition of an enzyme controlling an early stage of a series of biochemical reactions by the end product when it reaches a critical concentration * * * feedback inhibition, Biochemistry. a form of cellular control by which a mechanism… …   Useful english dictionary

  • feedback inhibition — noun Date: 1960 inhibition of an enzyme controlling an early stage of a series of biochemical reactions by the end product when it reaches a critical concentration …   New Collegiate Dictionary

  • feedback inhibition — The process by which the accumulated end product of a biochemical pathway stops synthesis of that product. The effect is that a late metabolite of a synthetic pathway regulates the synthesis of an earlier step of the pathway. See: end product… …   Glossary of Biotechnology

  • feedback inhibition — A negative feedback mechanism in which a pathway end product inhibits the activity of an enzyme in the sequence leading to its formation; when the end product accumulates in excess, it inhibits its own synthesis …   Dictionary of microbiology

  • inhibition — /in i bish euhn, in hi /, n. 1. the act of inhibiting. 2. the state of being inhibited. 3. something that inhibits; constraint. 4. Psychol. a. the blocking or holding back of one psychological process by another. b. inappropriate conscious or… …   Universalium

  • Feedback — Many biologic processes are controlled by feedback, just as the temperature in a home from a furnace is regulated by a thermostat. * * * 1. In a given system, the return, as input, of some of the output, as a regulatory mechanism; e.g.,… …   Medical dictionary

  • inhibition — 1. Depression or arrest of a function. SEE ALSO: inhibitor. 2. In psychoanalysis, the restraining of instinctual or unconscious drives or tendencies, especially if they conflict with one s conscience or with societal demands. 3. In psychology, a… …   Medical dictionary

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