Sherrington, Sir Charles Scott

born Nov. 27, 1857, London, Eng.

died March 4, 1952, Eastbourne, Sussex

English physiologist.

By studying animals whose cerebral cortexes had been removed, he showed that reflexes are integrated activities of the total organism, not based on isolated "reflex arcs." Sherrington's law states that when one set of muscles is stimulated, muscles opposing their action are inhibited. He showed that the role of proprioception in reflexes that maintain upright posture against gravity is independent of cerebral function and skin sensation. His work influenced the development of brain surgery and treatment of nervous disorders, and he coined the terms neuron and synapse. His classic work is The Integrative Action of the Nervous System (1906). In 1932 he shared a Nobel Prize with Edgar Adrian (1889–1977).

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▪ British physiologist

born Nov. 27, 1857, London, Eng.

died March 4, 1952, Eastbourne, Sussex

      English physiologist whose 50 years of experimentation laid the foundations for an understanding of integrated nervous function in higher animals and brought him (with Edgar Adrian (Adrian, Edgar Douglas Adrian, 1st Baron)) the Nobel Prize for Physiology or Medicine in 1932.

      Sherrington was educated at Gonville and Caius College, Cambridge (B.A., 1883); at St. Thomas' Hospital Medical School, where he qualified in medicine in 1885; and at the University of Berlin, where he worked with Rudolf Virchow and Robert Koch. After serving as a lecturer at St. Thomas' Hospital, he was successively a professor at the universities of London (1891–95), Liverpool (1895–1913), and Oxford (1913–35). He was made a fellow of the Royal Society in 1893 and served as its president from 1920 to 1925. He was knighted in 1922.

      Working with cats, dogs, monkeys, and apes that had been deprived of their cerebral hemispheres, Sherrington found that reflexes must be regarded as integrated activities of the total organism, not as the result of the activities of isolated “reflex arcs,” a notion that was currently accepted. The first major piece of evidence supporting “total integration” was his demonstration (1895–98) of the “reciprocal innervation” of muscles, also known as Sherrington's law: when one set of muscles is stimulated, muscles opposing the action of the first are simultaneously inhibited.

      In his classic work, The Integrative Action of the Nervous System (1906), he distinguished three main groups of sense organs: exteroceptive, such as those that detect light, sound, odour, and tactile stimuli; interoceptive, exemplified by taste receptors; and proprioceptive, or those receptors that detect events occurring in the interior of the organism. He found—especially in his study of the maintenance of posture as a reflex activity—that the muscles' proprioceptors and their nerve trunks play an important role in reflex action, maintaining the animal's upright stance against the force of gravity, despite the removal of the cerebrum and the severing of the tactile sensory nerves of the skin.

      His investigations of nearly every aspect of mammalian nervous function have directly influenced the development of brain surgery and the treatment of such nervous disorders as paralysis and atrophy. Sherrington also coined the terms neuron and synapse to denote the nerve cell and the point at which the nervous impulse is transmitted from one nerve cell to another, respectively. His books include The Reflex Activity of the Spinal Cord (1932).

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