hydroxyproline

hydroxyproline
/huy drok"si proh"leen, -lin/, n. Biochem.
a nutritionally nonessential amino acid, C5H9NO3, found chiefly in collagen.
[1900-05; HYDROXY- + PROLINE]

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      an amino acid formed upon hydrolysis of connective-tissue proteins such as collagen (about 14 percent by weight) and elastin but rarely from other proteins. The molecular structure of hydroxyproline contains a secondary amino group (>NH) rather than the primary amino group (-NH2) characteristic of most amino acids. First isolated (1902) from gelatin, a breakdown product of collagen, hydroxyproline is one of several so-called nonessential amino acids; i.e., animals can synthesize it from glutamic acid and do not require dietary sources. Excretion of abnormal quantities of hydroxyproline is a symptom of the connective-tissue disease called Marfan's syndrome.

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Universalium. 2010.

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  • hydroxyproline — n. A crystalline amino acid ({C5H9NO3}), a hydroxylated proline, obtained by hydrolysis of gelatin or collagen. Chemically it is 4 hydroxy L proline. It is classified as nonessential for growth in rats. [WordNet 1.5 +PJC] …   The Collaborative International Dictionary of English

  • hydroxyproline — [hī dräks΄ə prō′lēn΄, hī dräks΄ə prō′lin] n. a nonessential amino acid, HOC4H7NCOOH, found in connective tissue, esp. collagens …   English World dictionary

  • Hydroxyproline — L hydroxyproline est un acide aminé dérivé de la proline, celle ci étant alors hydroxylée. Elle fait donc comme cette dernière partie de la famille des acides aminés dérivés de la voie de biosynthèse du glutamate. Il existe en fait 8 formes d… …   Wikipédia en Français

  • Hydroxyproline — Chembox new ImageFile = Hydroxyproline structure.svg ImageSize = IUPACName = (2S,4R) 4 hydroxypyrrolidine 2 carboxylic acid OtherNames = Section1 = Chembox Identifiers CASNo = 51 35 4 PubChem = 825 SMILES = OC1CNC(C1)C(O)=O MeSHName =… …   Wikipedia

  • hydroxyproline — Specific proline residues on the amino side of a glycine residue in collagen become hydroxylated at C4, before the polypeptides become helical, by the activity of prolyl hydroxylase. This enzyme has a ferrous ion at the active site, and a… …   Dictionary of molecular biology

  • hydroxyproline — hy·droxy·pro·line prō .lēn n an amino acid C5H9NO3 that occurs naturally as a constituent of collagen * * * n. a compound, similar in structure to the amino acid, found only in collagen. * * * hy·droxy·pro·line (hi drok″se proґlēn) a… …   Medical dictionary

  • hydroxyproline — hidroksiprolinas statusas T sritis chemija formulė Formulę žr. priede. santrumpa( os) Pro(OH) priedas( ai) Grafinis formatas atitikmenys: angl. hydroxyproline rus. гидроксипролин ryšiai: sinonimas – 4 hidroksi 2 pirolidinkarboksirūgštis …   Chemijos terminų aiškinamasis žodynas

  • hydroxyproline — noun a crystalline amino acid obtained from gelatin or collagen • Hypernyms: ↑amino acid, ↑aminoalkanoic acid * * * “+ noun : a crystalline amino acid HOC4H7NCOOH obtained in the levorotatory l form especially by hydrolysis of gelatin or collagen …   Useful english dictionary

  • hydroxyproline oxidase — hy·droxy·pro·line ox·i·dase (hi drok″se proґlēn okґsĭ dās) an enzyme of the oxidoreductase class that catalyzes the oxidation of 4 hydroxyproline to form the 3 hydroxy analog of Δ1 pyrroline 5 carboxylate as part of the… …   Medical dictionary

  • hydroxyproline — noun Date: 1905 an amino acid C5H9NO3 that occurs naturally as a constituent of collagen …   New Collegiate Dictionary

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